1 Collagen - Coated 2 Poly ( lactide - co - glycolide ) / Hydroxyapatite Scaffold 3 Incorporated with DGEA Peptide for Synergistic 4 Repair of Skull Defect 5

نویسندگان

  • Shujun Dong
  • Ying Zhang
  • Weiguo Xu
  • Bitao Zhu
  • Jingyun Wang
  • Yanmin Zhou
  • Jianxun Ding
چکیده

The treatment of large-area bone defects remains a challenge; however, various strategies 20 have been developed to improve the performances of scaffolds in bone tissue engineering. In this 21 study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with 22 Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results 23 indicated that the mechanical strength and hydrophilicity of PLGA/HA scaffold were clearly 24 improved and conducive to cell adhesion and proliferation. The collagen-coated scaffold with 25 DGEA significantly promoted the repair of skull defect. These findings indicated that a combination 26 of collagen coating and DGEA improved scaffold properties for bone regeneration, thereby 27 providing a new potential strategy for scaffold design. 28 29

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Collagen-Coated Poly(lactide-co-glycolide)/Hydroxyapatite Scaffold Incorporated with DGEA Peptide for Synergistic Repair of Skull Defect

The treatment of large-area bone defects remains a challenge; however, various strategies have been developed to improve the performances of scaffolds in bone tissue engineering. In this study, poly(lactide-co-glycolide)/hydroxyapatite (PLGA/HA) scaffold was coated with Asp-Gly-Glu-Ala (DGEA)-incorporated collagen for the repair of rat skull defect. Our results indicated that the mechanical str...

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تاریخ انتشار 2018